[Answer] How do phospholipids interact with water molecules?

Answer: The polar heads interact with water; the nonpolar tails do not.

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How do phospholipids interact with water molecules? The phospholipids are amphiphilic. The hydrophilic end usually contains a negatively charged phosphate group and the hydrophobic end usually consists of two "tails" that are long fatty acid residues. In aqueous solutions phospholipids are driven by hydrophobic interactions that result in the fatty acid tails aggregating to minimize interactions with water molecules. The result is often a phospholipid bilayer: a membrane that consists of two layers of oppositely oriented phospholipid molecules with their heads e… Cell membranes are bilayer structures principally formed from phospholipids molecules which have a highly water interactive ionic phosphate head groups attached to two long alkyl tails. By contrast fluorosurfactants are not amphiphilic or detergents because fluorocarbons are not lipophilic. Protocell - Wikipedia Lipid bilayer - Wikipedia Amphiphile - Wikipedia Solvation - Wikipedia When phospholipids are exposed to water they self-assemble into a two-layered sheet with the hydrophobic tails pointing toward the center of the sheet. This arrangement results in two “leaflets” that are each a single molecular layer. When phospholipids are placed in water the molecules spontaneously arrange such that the tails are shielded from the water resulting in the formation of membrane structures such as bilayers vesicles and micelles. In modern cells vesicles are involved in metabolism transport buoyancy control and enzyme storage. Biological molecules are amphiphilic or amphipathic i.e. are simultaneously hydrophobic and hydrophilic. The phospholipid bilayer contains charged hydrophilic headgroups which interact with polar water . The layers also contain hydrophobic tails which meet with the hydrophobic tails of th...

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